Fat Melting Procedures: An Update
Injection lipolysis and mesotherapy are not one and the same. Lipodissolve is a trade name created to describe a patent-pending protocol that has been standardised since 2001. The theory of Lipodissolve was developed in the 1990s but the problem still remains that there are no conclusive outcomes from major trials worldwide on the use of such injections.
Currently, doctors have been considering injection lipolysis for cosmetic purposes with two central ingredients: phosphatidylcholine and deoxycholate (PC/DC formula):
- Phosphatidylcholine is a natural glycerolphospholipid comprised of glycerol, two fatty acids, and choline attached. Phosphatidylcholine is a fat emulsifier vital for cholesterol metabolism, and is a component of cell membranes. Phosphatidylcholine also can be found in foods and is currently a dietary supplement, taken in oral form. Although phosphatidylcholine is one of several ingredients used in certain FDA-approved intravenous drugs, it is not FDA-approved in combination with deoxycholate or for use in aesthetic intravenous purposes.
- Sodium deoxycholate, the active ingredient in PC/DC formulas, causes fat cells to undergo a process called oncosis when injected into the fatty layer. Oncosis is basically acute cellular swelling, and the damage caused to the cell membrane cannot be repaired by the cell in many cases. With deoxycholate alone, a very rapid onset of cell death is seen in a very localized region—within the immediate injection area. When phosphatidylcholine is added, the reaction is less harsh and is spread out a little more, causing a more even reduction of fat when the treatment area has a broad surface. A formula combining phosphatidylcholine and deoxycholate is currently the most popular fat-reducing injectable solution, based on its history of efficacy and safety when properly used by doctors. In addition, phosphatidylcholine acts as a buffer to the alkaline deoxycholate, which allows the reaction to progress over a week rather than several hours. More finesse and a smoother result can be seen when the two ingredients are combined.
On the other hand, a mesotherapy treatment may be comprised of many different ingredients. The selection of the ingredients is related to a specific procedure mesotherapy is intended to treat. Those ingredients may include vasodilators, anti-inflammatory drugs, muscle relaxants, proteolytic enzymes, vitamins, minerals, plant extracts, vaccines, antibiotics, hormones, hormone blockers, and anaesthetics. When we explore the history of mesotherapy in Europe, we learn that it is considered a credible procedure that is used for chronic pain and sports injuries. In truth, mesotherapy injection techniques are widely used throughout the world today.
We need to learn more about the effect of treatment of injection lipolysis on body fat mass, fat tissue metabolic function, and systematic markers of metabolism and inflammation; as well as determine mechanisms for fat reduction, side effects, and patient satisfaction. Questions about injection lipolysis still remain including what is the appropriate dose per injection and what is the appropriate total dose per body surface area.
In the future, injection lipolysis may be an adjunct to treatment or the only treatment for small fatty areas, but is unsuitable when compared to the results that can be accomplished through surgical treatment at present. Furthermore, it is my opinion that injection lipolysis should not be implemented in practices until it has been fully studied scientifically to help prove or disprove certain facts. It is our responsibility as doctors to inform and educate our patients and the public about these new treatments.
Tags: deoxycholate, injection lipolysis, mesotherapy, phosphatidylcholine
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August 16th, 2010 at 4:21 am
I had that done as well. The swelling will take at least 3 months to completly subside, so don’t be discouraged with your results until your body has had enough time to heal. Congrats on the lipo though and I really hope you are happy with it! Cheers
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